Brain arachnoiditis, symptoms of arachnoid cyst

...a cyst is not a tumor...

The most common type of brain cyst, occurring in 4% of the population, an arachnoid cyst is a cerebrospinal fluid (CSF)-filled sac located in the arachnoid membrane of the brain. At the site of the cyst, the tissue of the arachnoid membrane is divided into two layers with accumulation of fluid between them.

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It is important to remember that a cyst is not a tumor and in most cases is either asymptomatic or with minor manifestations and very rarely requires surgical intervention.

By origin, arachnoid cysts can be divided into:

Primary, formed during intrauterine development;
Secondary, arising as a result of injury or trauma, inflammatory processes occurring in the brain or bleeding.

According to the dynamics of development, there are cysts:

Progressive. This type of cyst is characterized by a gradual increase in symptoms associated with the fact that the cyst, increasing in volume, increases its pressure on the brain.
Frozen. These formations are stable and usually do not cause concern, often occur without symptoms, and some are detected only by chance during brain imaging caused by other reasons.

General information

Arachnoiditis is an infectious disease of the central nervous system and is a serous inflammation of the structures of the arachnoid membrane of the brain or spinal cord. The arachnoid membranes do not have their own vascular system, therefore the lesions are not isolated, and infectious processes spread from the dura or soft meninges, therefore the symptoms of arachnoiditis are conclusively attributed to the serous type of meningitis .
The pathology was described in most detail by the German doctor Benninghaus, and the term was first used in the dissertation of A.T. Tarasenkov, who studied the signs of cerebral inflammation and arachnoiditis in particular. Some scientists call this disease serous meningitis, but according to ICD-10 it is assigned the code G00 and the name bacterial arachnoiditis , G03 - which includes meningitis due to other or unspecified causes, including arachnoiditis , meningitis , leptomeningitis , pachymeningitis , as well as G03 .9 – for unspecified meningitis – spinal arachnoiditis NOS (no additional instructions).

The brain has three membranes: hard, arachnoid and soft. Thanks to the hard one, sinuses are formed for the outflow of venous blood, the soft one provides trophism, and the arachnoid one is necessary for the circulation of cerebrospinal fluid . It is located above the gyri, but does not penetrate the sulci of the brain and separates the subarachnoid and subdural space. Its structure contains arachnoidendothelial cells, as well as bundles of collagen fibrils of varying thickness and quantity.

Histology of the meninges

General principles of therapy

Drug therapy for cystic formations has practically no results. The only possible treatment is surgical removal of the fluid cavity. But, most forms are small in size and remain in a “dormant” state for many years. In this case, no methods of therapy are used; a wait-and-see regimen is chosen and the patient is regularly examined.

Formations that are accompanied by symptoms of hydrocephalus, complicated by bleeding and rupture, compressing the brain and rapidly increasing in size must be removed. Only a neurosurgeon decides which method of surgical treatment to use.

If the patient has a disorder of consciousness (coma or stupor), he is urgently referred to external ventricular drainage. This method allows you to reduce compression of the brain by the cyst and intracranial pressure. If the cyst ruptures or hemorrhages, surgery is performed. The patient undergoes craniotomy and the formation is excised.

In the absence of complications and disturbances of consciousness, the operation is performed planned and endoscopically. The advantage is the patient’s quick recovery period and low trauma. With endoscopic access, a milling hole is made in the skull, through which fluid is sucked out from the cavity. In order to avoid subsequent accumulation of fluid, several holes are made in the cavity (connected to the cerebrospinal fluid space) or cystoperiotoneal shunting is performed (a special shunt is installed).

The postoperative period involves rehabilitation therapy, including exercise therapy, reflexology and massage. The patient is prescribed drugs to improve blood supply to the brain, absorbents and decongestants.

Pathogenesis

Arachnoiditis causes morphological changes in the form of clouding and thickening of the arachnoid membrane, which may be complicated by fibrinoid deposits. Most often they are diffuse, but in some cases they can be limited, that is, we are talking about more severe local disorders initiated by an extensive process of arachnoiditis. Macroscopic changes in this case are:

clouding and thickening (hyperplasia of the arachnoid endothelium) of the arachnoid membrane, its fusion with the choroid and dura mater of the brain;
diffuse infiltration;
expansion of subarachnoid slit-like formations and cisterns at the base of the brain, development of their hydrops (overflow of cerebrospinal fluid).

The further course of the pathology leads to fibrosis and the formation of adhesions between the choroid and arachnoid membrane, impaired circulation of the cerebrospinal fluid (cerebrospinal fluid) and the formation of one or more arachnoid cysts. In this case, the normal circulation of the liquor fluid is disrupted and, as a result, hydrocephalus , the mechanism of which is based on two development paths:

occlusive - resulting from a violation of the outflow of fluid from the ventricular system, for example, the closure of the Luschka or Magendie holes by the resulting adhesions or cysts;
aresorptive – in which the processes of fluid absorption through the structures of the dura mater are disrupted, as a result of a diffuse “adhesive” process.

Why is the disease dangerous?

A cerebrospinal fluid cyst, if not properly treated, can become a dangerous disease with serious complications and tragic consequences. It entails disability, and in isolated cases even death.

With timely assistance, the prognosis is more than favorable. The risk of worsening the condition is reduced. Otherwise, a number of conditions may develop:

Neurological disorders. These include disturbances in motor activity, loss of sensitivity, and disruptions in the functioning of the nervous system.
Epilepsy, frequent convulsions, involuntary movements of arms and legs, loss of consciousness.

Strict adherence to all doctor’s prescriptions will help prevent their development.

Arachnoid cysts do not pose a serious danger for the time being. They do not manifest themselves in any symptoms and are detected only during a routine examination. But sometimes, due to an increase in the amount of fluid, they begin to grow. In such situations, the person’s condition noticeably worsens and requires medical intervention.

Classification

There are several classifications of arachnoiditis. Based on the established cause, arachnoiditis can be post-traumatic, infectious (rheumatic, post-influenza, tonsillitis) and toxic, depending on the type of changes - cystic, adhesive-cystic, limited and diffuse, single-focal and multifocal.

Depending on the clinical picture and course, acute, subacute and chronic arachnoiditis are distinguished, but for diagnosis it is most important to determine the location of arachnoiditis and predict the pattern of exposure and consequences of membrane lesions.

Depending on the predominant location and structures involved in the pathology, arachnoiditis can be of various types: cerebral, basal, opto-chiasmal, pontocerebellar, precerebellar, spinal, etc.

Cerebral arachnoiditis

The cerebral type of arachnoiditis usually covers the membranes of the brain of the anterior parts of the cerebral hemispheres and areas of the central gyri, affecting not only the archnoid endothelium, but also the structures of the soft medulla with the formation of adhesions between them. As a result of the adhesive process, cysts with liquor-like contents are formed. Thickening and compaction of cysts can lead to xanthochromic tumor-like formations containing large amounts of protein, which can manifest as the development of status epilepticus .

Arachnoid cyst of the brain

Optico-chiasmatic arachnoiditis

It is most often localized in the chiasmal region and affects the base of the brain, involving the optic nerves and their chiasm in the pathology. This is facilitated by traumatic brain injuries (concussion or contusion), infectious processes in the paranasal sinuses, as well as diseases such as tonsillitis, syphilis or malaria . Its result can be irreversible vision loss, which begins with pain behind the eyeballs and visual impairment, which can lead to unilateral and bilateral temporal hemianopia, central scotoma , concentric narrowing of the visual fields.

The development of pathology is slow and not strictly local; it can spread to areas distant from the chiasm, usually accompanied by the formation of multiple adhesions, cysts, and even the formation of a scar membrane in the chiasm area. A negative effect on the optic nerves causes their atrophy - complete or partial, which is ensured by mechanical compression by adhesions, the formation of congestive nipples and blood circulation disorders ( ischemia ). In this case, initially one of the eyes suffers more, and after a few months the second one is also involved.

Spinal arachnoiditis

In addition to these well-known causes, spinal arachnoiditis can be caused by furunculosis and purulent abscesses of various locations. In this case, cystic limited formations cause symptoms similar to an extramedullary tumor, symptoms of compression of spinal cord structures, as well as radicular syndrome and conduction disorders, both motor and sensory.

Chronic inflammatory processes cause protein-cell dissociation of the cerebrospinal fluid and most often affect the posterior surface of the thoracic, lumbar or cauda equina spinal cord. They can spread to several roots or, in case of diffuse lesions, to a large number, changing the lower limit of the sensitivity disorder.

Spinal archnoiditis can be expressed as:

in the form of tingling, numbness, weakness in the legs, unusual sensations in the limbs;
the occurrence of leg cramps, muscle spasms, spontaneous twitching;
in the form of a disorder (increase, loss) of such reflexes as knee, heel;
attacks of severe shooting pain like electric shocks or, on the contrary, aching pain in the lower back;
disruption of the pelvic organs, including decreased potency .

Irritation and compression of the cortex and nearby parts of the brain during arachnoiditis can be complicated by the formation of cysts of various types - retrocerebellar, cerebrospinal fluid, left or right temporal region.

Retrocerebellar arachnoid cyst

A retrocerebellar cyst is formed when the choroid plexus of the fourth ventricle is displaced upward and backward from the intact vermiform part of the cerebellum. To identify this type of cyst, CT and MRI are approximately equally informative.

Arachnoid cerebrospinal fluid cyst

It is customary to distinguish between intracerebral and subarachnoid cerebrospinal fluid cysts, the former are more common in adults, and the latter are more typical for pediatric patients, which is very dangerous and causes mental retardation.

Liqueur cysts are formed by arachnoid endothelium or scar collagen and filled with cerebrospinal fluid. They can be congenital or formed during the resorption of intracerebral hemorrhages, foci of bruises and crush injuries of the brain, in the zone of ischemic softening after injuries. They are characterized by a long-term remitting course, initiating epileptic seizures of different structure, duration and frequency.

A cerebrospinal fluid cyst can also occur as a result of subarachnoid hemorrhage or reactive adhesive leptomeningitis.

Arachnoid cyst of the right temporal region

A cyst in the right temporal region can cause headaches, a sensation of pulsation, squeezing of the head, noise in the ear, attacks of nausea, convulsions , and uncoordination of movements.

Arachnoid cysts are frozen, stable and most often do not cause discomfort or cerebral disorders. An asymptomatic course can lead to the formation being detected only during a brain tomography if arachnoiditis is suspected.

Arachnoid cyst of the left temporal lobe

If the left temporal lobe cyst is progressive, then it can gradually increase focal symptoms due to pressure on the brain. It is usually located in the left temporal lobe and looks like an extension of the external cerebrospinal fluid space.

When a patient learns about a cyst in the left temporal region, it often turns out that it is not fatal and may not cause negative symptoms. However, in some cases there is a risk of developing speech disorders (sensory aphasia ), loss of visual fields, sudden spasms of the limbs or the whole body.

Dimensions of education

The sizes of education vary, but three groups are conventionally distinguished. It is worth noting that the size of the cyst may be within normal limits, that is, not regarded as dangerous. There are the following education parameters:

Initial stage cyst - up to 2 mm;
Moderate cyst - from 2 to 10 mm;
Large cyst - from 10 mm in thickness and at least 13 cm in length.

REFERENCE! The cyst may have minimal dimensions for a long time, and then suddenly begin to grow, or immediately increase at a high speed, or remain small and not grow at all.

Useful video on the topic:

Causes

There are several ways of developing inflammation of the arachnoid membranes and it has been established that arachnoiditis is polyetiological and can occur as a result of such factors as:

past acute and chronic infectious processes (including influenza , rheumatism, measles , fever , sepsis , pneumonia , syphilis , tuberculosis , brucellosis , toxoplasmosis , osteomyelitis of the skull bones);
inflammatory diseases of the nasal paranasal sinuses;
acute or more often chronic suppurative otitis media , especially caused by low-virulent microorganisms or toxins;
complication of suppurative otitis media, for example, labyrinthitis , petrositis , sinus thrombosis ;
complication of cured purulent meningitis or brain abscesses;
chronic intoxication with alcohol, lead, arsenic ;
various injuries - craniocerebral and spinal cord (mainly as residual effects);
reactive inflammation caused by slowly growing tumors or encephalitis, most often non-purulent otogenic.

Possible complications

If a person postpones a visit to the doctor for a long time, ignores the symptoms, in general, does everything to ensure that the disease reaches an advanced stage, serious complications may arise.
The main ones are:

Incessant pressing headaches;
When a specific area of the brain is damaged, any functions are lost (for example, the vestibular apparatus, speech center, etc.);
Convulsive and epileptic seizures (mainly in children);
Increased intracranial pressure , sensitivity to long journeys;
Weakening of the immune system , and as a result - frequent illnesses;
Deviant behavior or communication difficulties, increased or decreased activity.

No additional growths, tumors or formations in the human body can be useful or even harmless. If there is an excess of something somewhere, then you need to find out the cause and eliminate it.

A retrocerebellar arachnoid cyst is located deep in the skull, and, of course, it is impossible to detect it on your own. It is important to listen to your body and pay attention even to a symptom such as a headache.

Sometimes even a few hours play a role between the time when taking medication can still save you and the time when urgent surgical intervention is required.

Symptoms of brain arachnoiditis

Symptoms of arachnoiditis are usually caused by intracranial hypertension , in more rare cases by liquor hypotension , as well as manifestations reflecting localization affecting the meningeal processes. Moreover, general or local symptoms may predominate, depending on this, the first symptoms and the clinical picture changes.

The initial subacute course of the disease can eventually turn into a chronic form and manifest itself in the form of general cerebral disorders:

local headaches , the most intense - in the first half of the day can cause nausea and vomiting ;
development of the jumping symptom , when pain occurs locally during jumping or an awkward, unabsorbed movement with landing on the heels;
dizziness of a non-systemic nature;
sleep disorders;
memory impairment;
mental disorders;
the occurrence of causeless irritability, general weakness and increased fatigue.

Focal disorders primarily depend on the location of the development of the pathology and can manifest themselves in the form of symptoms of damage to the trigeminal, abducens, auditory and facial nerves. Besides:

With convexital (convex) arachnoiditis, inflammatory processes affect areas of the central gyri and anterior parts of the cerebral hemispheres, while the phenomena of irritation of brain structures predominate over manifestations of loss of functions, which are expressed in the form of anisoreflexia , central paresis , generalized and Jacksonian epileptic seizures , impaired circulation of cerebrospinal fluid, disorders of sensitivity and movement ( mono- or hemiparesis ).
With inflammation of the basal sections (optic-chiasmatic, cerebellopontine and in the region of the postcranial fossa), general cerebral symptoms most often occur and the functions of the nerves of the base of the skull are disrupted.
Optico-chiasmatic arachnoiditis is manifested by a decrease in visual acuity and changes in fields, resembling optic neuritis and combined with autonomic dysfunction - severe dermographism , increased pilomotor reflex, profuse sweating, acrocyanosis , sometimes thirst , increased urination, hyperglycemia , adiposogenital obesity , decreased sense of smell.
Pathology affecting the region of the cerebral peduncles causes pyramidal symptoms, as well as signs of damage to the oculomotor nerves and meningeal signs.
Arachnoiditis of the cerebellopontine angle causes headaches in the occipital region, tinnitus, neuralgia , paroxysmal dizziness, sometimes with vomiting, unilateral cerebellar disorders - when the patient staggers or supports weight on one leg, the fall occurs on the affected side; a thorough examination can reveal an ataxic gait , horizontal nystagmus , pyramidal symptoms, dilatation of the veins of the fundus, provoked by disturbances of the venous outflow.
If the large (occipital) cistern is affected, the disease develops acutely with fever, obsessive vomiting, pain in the back of the head and cervical region, which intensifies when coughing, trying to turn the head or make a sudden movement.
Localization of inflammatory processes in the area of IX, X, XII pairs of cranial nerves leads to nystagmus , increased tendon reflexes, pyramidal and meningeal symptoms.
Arachnoiditis of the posterior cranial fossa can affect the V, VI, VII, VIII pair of cranial nerves and cause intracranial hypertension with meningeal symptoms, cerebellar and pyramidal disorders, for example, ataxia , asynergia , nystagmus , adiadochokinesis , headache becomes a constant symptom, one of the earliest .
Diffuse damage is provoked by general cerebral phenomena and uneven expansion of the ventricles, which is expressed in the occurrence of frontal, hypothalamic, temporal, midbrain and cortical syndrome; the pathology initiates a disruption of the normal exchange of cerebrospinal fluid, vague pyramidal symptoms, and can affect individual cranial nerves.

Clinical course of the disease in a child

In a small patient, the development of this pathology is accompanied, as in an adult, by a number of similar signs:

hearing impairment;
paralysis and paresis of limbs;
cramps, numbness;
impaired coordination of motor activity.

If the cyst progresses in size, intracranial pressure may increase, which as a result affects the appearance of the following symptoms:

vomit;
intense headaches;
pulsation in the head area;
increased drowsiness and fatigue.

A more severe degree of the disease causes divergence of the bone sutures (problems with the overgrowth of the fontanel in infants), which affects the delay in the development of the baby, both mental and physical.

Tests and diagnostics

When making a diagnosis, a differential diagnosis must be made with abscesses and neoplasms in the posterior cranial fossa or other parts of the brain. To determine arachnoiditis, it is important to conduct a comprehensive and detailed examination of the patient.

Electroencephalography , angiography , pneumoencephalogram , scintigraphy , survey craniograms , skull x-ray, myelography , CT, MRI are indicative These studies make it possible to identify intracranial hypertension, local changes in biopotentials, expansion of the subarachnoid space, cisterns and ventricles of the brain, cystic formations and focal changes in the brain substance. Only if there is no congestion in the fundus, then a lumbar puncture to detect moderate lymphocytic pleocytosis and slight protein-cell dissociation. In addition, it may be necessary to perform an index and finger-nose test.

Prevention

Prevention of congenital cerebrospinal fluid cysts is based on the prevention of congenital malformations and includes the following areas:

eliminating the impact of teratogenic factors on a pregnant woman;
rational management of pregnancy;
careful delivery.

Prevention of acquired cerebrospinal fluid cysts is based on timely and complete treatment of vascular and inflammatory cerebral diseases, traumatic brain injuries.

Diet for arachnoiditis

Diet for the nervous system

Efficacy: therapeutic effect after 2 months
Timing: constantly
Cost of food: 1700-1800 rubles per week

Treatment of arachnoiditis is best combined with a diet based on the principles of healthy eating:

limited consumption of seasonings and salt;
products containing refined sugar, butter, flour are excluded;
meat should be of dietary grades - rabbit, turkey, chicken, etc.;
no sausages or smoked meats;
there should be fresh vegetables and fruits on the table;
You need to enrich your diet with baked potatoes, cabbage and carrot salads, spicy and leafy greens;
you need to add currants, sea buckthorn, persimmons, grapes, and raisins to dishes and teas.

Functional significance of the gland

The significance of the pineal gland is not fully understood; it is too small and deeply located. But the hormones that it produces have been identified: melatonin, serotonin, pinealin, adrenoglomerulotropin, dimethyltryptamine.

Serotonin is a precursor to melatonin and is involved in the regulation of circadian rhythms (sleep and wakefulness). 80% of melatonin is produced in the pineal gland. Melatonin inhibits the development of the gonads in children, affecting the gonadotropic hormone. To produce it, absolute darkness is needed, otherwise its synthesis immediately stops. Therefore, the formation of melatonin occurs during night sleep. With the end of puberty, production decreases.

The pineal gland in children affects the functioning of the entire endocrine system: the thyroid gland, adrenal glands and pituitary gland. It not only participates in the regulation of sexual development, but is also a connecting element between the tissues of the cerebral cortex. In addition, the pineal gland reduces the production of growth hormone, inhibits sexual behavior, the development of tumors, and is responsible for orientation in space and time; regulates the exchange of Ca, P, K, magnesium; regulates seasonal rhythms; has antioxidant properties, exhibits antitumor protection, and delays aging.

Serotonin is not only a precursor to melatonin, but is also considered the hormone of happiness, creates a good mood and improves emotional background. Adrenoglomerulotropin - regulates the production of adrenal hormones, stimulates the production of aldosterone, thus participating in electrolyte metabolism.

Pinealin lowers blood sugar. Little studied.

Dimethyltryptamine (DMT) is responsible for dreams and clairvoyance, near-death experiences.

For centuries, the pineal gland was considered the seat of the soul, in esotericism - the third eye, determining the ability to clairvoyance and transmit information at a distance - telepathy.

Apparently, this is due to the fact that the pineal gland itself can perform rotational movements, reminiscent of the movements of the eyeball.

In addition, the structure of the gland contains rudimentary elements like a lens and some receptors reminiscent of the eyeball, but they are underdeveloped.

The pineal gland in children actively grows, but already from adolescence its growth gradually decreases. With age, it begins to involute and its activity decreases.

Radical treatment methods

Shunting - a drainage is installed, with the help of which the cyst is emptied, after which its walls fall off and become overgrown. But surgery can often have negative consequences for the body due to the complexity of the brain structure.

Endoscopy – the cyst is removed through a puncture in the skull. This method does not cause complications, but there are contraindications in the form of visual impairment.

Craniotomy is an effective operation where a specific area of the skull is removed to gain access to the brain. Has a high risk of brain damage.

Treatment of epiphysis cyst

In most cases, treatment of pineal cysts does not require the use of drugs. The use of drugs is possible only for echinococcosis, at its earliest stage. Symptomatic treatment to eliminate the manifestations of the disease is prescribed only when they appear. And this happens when the blood vessels of the brain or its tissues are compressed by a growing cyst. Or surgical treatment is used - most often. Due to the complexity of access, operations are difficult and there is a high percentage of complications - 60-70%.

Indications for surgery:

severe symptoms;
parasitic nature of the cyst;
cyst growth;
hydrocephalus;
influence on the cardiovascular system.

If pathology is identified, further treatment of a cyst in the pineal region of the brain is aimed at reducing the risk of its growth.